abstract：:Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 1...

journal_title：Frontiers in psychiatry

authors： de Beaurepaire R

更新日期：2014-10-10 00:00:00

abstract：:Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency as well as body representations that deal with body ...

journal_title：Frontiers in psychiatry

authors： Graham KT,Martin-Iverson MT,Holmes NP,Jablensky A,Waters F

更新日期：2014-09-10 00:00:00

abstract：:The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initia...

journal_title：Frontiers in psychiatry

authors： Hsu WC,Nilsson CL,Laezza F

更新日期：2014-08-21 00:00:00

abstract：:Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has n...

journal_title：Frontiers in psychiatry

authors： Thorsen AL,Johansson K,Løberg EM

更新日期：2014-08-15 00:00:00

abstract：:Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single g...

journal_title：Frontiers in psychiatry

authors： Tordjman S,Somogyi E,Coulon N,Kermarrec S,Cohen D,Bronsard G,Bonnot O,Weismann-Arcache C,Botbol M,Lauth B,Ginchat V,Roubertoux P,Barburoth M,Kovess V,Geoffray MM,Xavier J

更新日期：2014-08-04 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). It is characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This het...

journal_title：Frontiers in psychiatry

authors： Briscione MA,Jovanovic T,Norrholm SD

更新日期：2014-07-21 00:00:00

abstract：:Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertai...

journal_title：Frontiers in psychiatry

authors： Coelho JE,Alves P,Canas PM,Valadas JS,Shmidt T,Batalha VL,Ferreira DG,Ribeiro JA,Bader M,Cunha RA,do Couto FS,Lopes LV

更新日期：2014-06-13 00:00:00

abstract：:Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on a whole brain basis. However, it is often criticized for potential confounds, mainly based on imperfect spatial registration. We therefore aimed to evaluate if VBM and "gold standard" manual volumetry are measuring the same effec...

journal_title：Frontiers in psychiatry

authors： Focke NK,Trost S,Paulus W,Falkai P,Gruber O

更新日期：2014-04-08 00:00:00

abstract：:This article discusses yoga as a potential tool for children to deal with stress and regulate themselves. Yoga provides training of mind and body to bring emotional balance. We argue that children and young people need such tools to listen inward to their bodies, feelings, and ideas. Yoga may assist them in developing...

journal_title：Frontiers in psychiatry

authors： Hagen I,Nayar US

更新日期：2014-04-02 00:00:00

abstract：:Imaging studies of major depressive disorder (MDD) have demonstrated enhanced resting-state activity of the amygdala as well as exaggerated reactivity to negative emotional stimuli relative to healthy controls (HCs). However, the abnormalities in the intrinsic connectivity of the amygdala in MDD still remain unclear. ...

journal_title：Frontiers in psychiatry

authors： Ramasubbu R,Konduru N,Cortese F,Bray S,Gaxiola-Valdez I,Goodyear B

更新日期：2014-02-19 00:00:00

abstract：:Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

journal_title：Frontiers in psychiatry

authors： Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Evidence indicates that early life stress (ELS) can induce persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis to respond to stress in the adult life that leads to depression. These appear to be related to the impairment of HPA hormones through binding to glucocorticoid (GR) and mineralocorti...

journal_title：Frontiers in psychiatry

authors： Baes Cv,Martins CM,Tofoli SM,Juruena MF

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Electroconvulsive therapy (ECT) is effective in the treatment of major depressive disorder and schizophrenia in patients who are drug-naïve or less-receptive to antipsychotic drugs. Several studies have discussed the correlation between patient characteristics, input-current volume, and seizure duration. Acc...

journal_title：Frontiers in psychiatry

authors： Wang CC,Lin CH,Chiu YC,Tseng CC

更新日期：2013-12-23 00:00:00

abstract：:Recent work on the mechanisms underlying auditory verbal hallucination (AVH) has been heavily informed by self-monitoring accounts that postulate defects in an internal monitoring mechanism as the basis of AVH. A more neglected alternative is an account focusing on defects in auditory processing, namely a spontaneous ...

journal_title：Frontiers in psychiatry

authors： Cho R,Wu W

更新日期：2013-11-27 00:00:00

abstract：BACKGROUND:The treatment of cocaine-dependent individuals (CDI) is substantially challenged by high drop-out rates, raising questions regarding contributing factors. Recently, a number of studies have highlighted the potential of greater focus on the clinical significance of neurocognitive impairments in treatment-seek...

journal_title：Frontiers in psychiatry

authors： Stevens L,Betanzos-Espinosa P,Crunelle CL,Vergara-Moragues E,Roeyers H,Lozano O,Dom G,Gonzalez-Saiz F,Vanderplasschen W,Verdejo-García A,Pérez-García M

更新日期：2013-11-15 00:00:00

abstract：:Cognitive neuroscience enables us now to decompose major depressive disorder into dysfunctional component processes and relate these processes to specific neural substrates. This approach can be used to illuminate the biological basis of altered psychological processes in depression, including abnormal decision-making...

journal_title：Frontiers in psychiatry

authors： Howlett JR,Paulus MP

更新日期：2013-11-08 00:00:00

abstract：UNLABELLED:Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight (1) differences in infere...

journal_title：Frontiers in psychiatry

authors： Burns RM,Caulkins JP,Everingham SS,Kilmer B

更新日期：2013-11-06 00:00:00

abstract：:Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temp...

journal_title：Frontiers in psychiatry

authors： Denier N,Schmidt A,Gerber H,Schmid O,Riecher-Rössler A,Wiesbeck GA,Huber CG,Lang UE,Radue EW,Walter M,Borgwardt S

更新日期：2013-10-21 00:00:00

abstract：:The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

journal_title：Frontiers in psychiatry

authors： Burns JK

更新日期：2013-10-14 00:00:00

abstract：:What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

journal_title：Frontiers in psychiatry

authors： Kennett J,Matthews S,Snoek A

更新日期：2013-09-25 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates ...

journal_title：Frontiers in psychiatry

authors： Xu J,Fregni F,Brody AL,Rahman AS

更新日期：2013-09-20 00:00:00

abstract：:Abnormalities in EEG gamma band oscillations (GBO, 30-80 Hz) serve as a prominent biomarker of schizophrenia (Sz), associated with positive, negative, and cognitive symptoms. Chronic, subanesthetic administration of antagonists of N-methyl-D-aspartate receptors (NMDAR), such as ketamine, elicits behavioral effects, an...

journal_title：Frontiers in psychiatry

authors： McNally JM,McCarley RW,Brown RE

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:A small number of previous studies have provided evidence that cocaine users (CU) exhibit impairments in complex social cognition tasks, while the more basic facial emotion recognition is widely unaffected. However, prosody and cross-modal emotion processing has not been systematically investigated in CU so ...

journal_title：Frontiers in psychiatry

authors： Hulka LM,Preller KH,Vonmoos M,Broicher SD,Quednow BB

更新日期：2013-09-05 00:00:00

abstract：:Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana ...

journal_title：Frontiers in psychiatry

authors： Lisdahl KM,Gilbart ER,Wright NE,Shollenbarger S

更新日期：2013-07-01 00:00:00

abstract：:Molecular mechanisms in the brain are assumed to cause the symptoms and severity of neuropsychiatric disorders. This review concerns the elusive nature of relationships between the severity of depressive disorders and neuromolecular processes studied by positron emission tomography (PET). Recent PET studies of human d...

journal_title：Frontiers in psychiatry

authors： Smith DF,Jakobsen S

更新日期：2013-03-04 00:00:00

abstract：STUDY OBJECTIVE:Animal data suggest that Δ(9)-TetraHydroCannabinol (Δ(9)THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep apnea. On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)THC), an e...

journal_title：Frontiers in psychiatry

authors： Prasad B,Radulovacki MG,Carley DW

更新日期：2013-01-22 00:00:00

abstract：:Incarceration affects the lives of many African American men and often leads to poverty, ill health, violence, and a decreased quality of life. There has been an unprecedented increase in incarceration among African American males since 1970. In 2009, the incarceration rate among black males was 6.7 times that of whit...

journal_title：Frontiers in psychiatry

authors： Mukku VK,Benson TG,Alam F,Richie WD,Bailey RK

更新日期：2012-11-12 00:00:00

abstract：:In a group of 1066 heroin addicts, who were seeking treatment for opioid agonist treatment, we looked for differences in historical, demographic, and clinical characteristics, between patients with different levels of awareness of illness (insight). The results showed that, in the cohort studied, a majority of subject...

journal_title：Frontiers in psychiatry

authors： Maremmani AG,Rovai L,Rugani F,Pacini M,Lamanna F,Bacciardi S,Perugi G,Deltito J,Dell'osso L,Maremmani I

更新日期：2012-07-09 00:00:00

abstract：:Combined administration of transcranial direct current-stimulation (tDCS) with either pergolide (PER) or d-cycloserine (d-CYC) can prolong the excitability-diminishing effects of cathodal, or the excitability enhancing effect of anodal stimulation for up to 24 h poststimulation. However, it remains unclear whether the...

journal_title：Frontiers in psychiatry

authors： Chaieb L,Antal A,Terney D,Paulus W

更新日期：2012-07-05 00:00:00

abstract：INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...

journal_title：Frontiers in psychiatry

authors： Greenstein D,Malley JD,Weisinger B,Clasen L,Gogtay N

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Emerging evidence indicates that nicotine dependence should be measured multidimensionally. A brief version of the Wisconsin Inventory of Smoking Dependence Motives (WISDM) has recently been developed in which the item count has been reduced from 68 to 37. The objectives of this study were to replicate the...

journal_title：Frontiers in psychiatry

authors： Ma JZ,Li MD,Payne TJ

更新日期：2012-04-26 00:00:00

abstract：INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...

journal_title：Frontiers in psychiatry

authors： Perez-Costas E,Melendez-Ferro M,Rice MW,Conley RR,Roberts RC

更新日期：2012-04-09 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are characterized by the misfolding of the host encoded prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)) which leads to the accumulation of β-sheet-rich fibrils and subsequent loss of neurons and synaptic functions. Although many compounds have been identified ...

journal_title：Frontiers in psychiatry

authors： Eiden M,Leidel F,Strohmeier B,Fast C,Groschup MH

更新日期：2012-02-17 00:00:00

abstract：:THE MIRROR SYSTEM HYPOTHESIS AND INVESTIGATIONS OF BIRDSONG ARE REVIEWED IN RELATION TO THE SIGNIFICANCE FOR THE DEVELOPMENT OF HUMAN SYMBOLIC AND LANGUAGE CAPACITY, IN TERMS OF THREE FUNDAMENTAL FORMS OF COGNITIVE REFERENCE: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to inde...

journal_title：Frontiers in psychiatry

authors： Levy F

更新日期：2012-01-11 00:00:00

abstract：:Previous work from our group and others utilizing animal models have demonstrated long-lasting structural and functional alterations in the meso-cortico-striatal dopamine pathway following prenatal cocaine (PCOC) treatment. We have shown that PCOC treatment results in augmented D1-induced cyclic AMP (cAMP) and cocaine...

journal_title：Frontiers in psychiatry

authors： Tropea TF,Kabir ZD,Kaur G,Rajadhyaksha AM,Kosofsky BE

更新日期：2011-12-07 00:00:00

abstract：:Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevale...

journal_title：Frontiers in psychiatry

authors： Meule A

更新日期：2011-11-03 00:00:00

abstract：:One clue regarding the basis of cocaine-induced deficits in attentional processing is provided by the clinical findings of changes in the infants' startle response; observations buttressed by neurophysiological evidence of alterations in brainstem transmission time. Using the IV route of administration and doses that ...

journal_title：Frontiers in psychiatry

authors： Mactutus CF,Harrod SB,Hord LL,Moran LM,Booze RM

更新日期：2011-06-28 00:00:00

abstract：PURPOSE:Excessive daytime sleepiness is highly prevalent in the general population, is the hallmark of narcolepsy, and is linked to significant morbidity. Clinical assessment of sleepiness remains challenging and the common objective multiple sleep latency test (MSLT) and subjective Epworth sleepiness scale (ESS) metho...

journal_title：Frontiers in psychiatry

authors： Prasad B,Choi YK,Weaver TE,Carley DW

更新日期：2011-06-07 00:00:00

abstract：:Autism spectrum condition (ASC) is recognized as having an inflammatory component. Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the underlying molecular mechanisms. Nuclear factor kappa-light-chain-enhance...

journal_title：Frontiers in psychiatry

authors： Young AM,Campbell E,Lynch S,Suckling J,Powis SJ

更新日期：2011-05-13 00:00:00

abstract：:Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, and it refers to both a state symptom in various psychiatric disorders and a personality trait. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Anhedonia...

journal_title：Frontiers in psychiatry

authors： Hatzigiakoumis DS,Martinotti G,Giannantonio MD,Janiri L

更新日期：2011-03-17 00:00:00